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![]() How To Use An Amazon S3 Connection Profile for Google Cloud Access How to set up a ChronoAgent connection profile so that you can sync and backup to a remote Mac.Ĭonfigure And Backup To Google Cloud StorageĮxplains how to set up a Google Cloud account and then use the Google Cloud credentials to set up a connection profile and backup to the cloud service. Various methods of how to connect your Mac directly to another Mac to backup or sync files.Ĭonfigure And Backup To A Remote ChronoAgent ![]() Various methods to connect a Mac over a wired or wireless network to another Mac, another computer, NAS drive or an external drive on another computer. The steps the assistant takes to modify various settings used to monitor the status of one or more sync/backup tasks. The steps the assistant takes to convert applicable targets to Admin Access on one or more sync/backup tasks. The steps the assistant takes to schedule one or more sync/backup tasks to run automatically. The steps the assistant takes to modify the error handling behaviors of one or more sync/backup tasks. The steps the assistant takes to backup multiple folders to the same location on another volume. The steps the assistant takes to make a backup copy of any folder onto another volume. The steps the assistant takes to make two folders identical to each other by setting up a bidirectional synchronization. The steps the assistant takes to make a backup copy of any folder onto a mounted disk image. The steps the assistant takes to make a bootable clone of your system drive onto another drive. The steps the assistant takes to make a backup copy of your home folder onto another volume. Watch and follow along with these videos to learn how to schedule sync documents to run automatically, how to use advanced scheduling options and how to use the Scheduled Documents Manager Window in ChronoSync. 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Also, it was difficult getting the heat sink off the processor after removing the pins. I broke one of the plastic post retaining thingys while removing the processor heat sink but fortunately I ordered some replacement plastic screws ahead of time.Īlso, I bought the two small bottles of stuff to remove the old thermal paste and I found I had to work away at it several times using a credit card to get the paste of the heat sink and the processor. I know I can update the "bios" to 2,1 and also get Lion operational by deleting the hidden. I ordered another new 2GB stick so that I could use 3GB RAM when operating with Lion OS. I had to remove the old stick for the machine to come up. ![]() I found that using one of the old 1GB memory sticks with a new 2GB stick did not work. ![]() I updated a Mac Mini A1176 1.66 GHz Core Duo with the following: So you want a fast Mac Mini but not a hot one! We have enough fans blowing around us :-) I used then only enough Arctic Silver to cover the contact area before putting it together again. So after some advice I took it apart and removed all the paste from the CPU sink. I got my MacBook Pro (2007) back from Apple for a free logic board replacement. The Mac Mini does not have very good cooling structure. I would say too much is worse than too little. I think it is very important to use thermal paste like Arctic Silver and use very little paste. I was very satisfied with my Core Duo 2Ghz upgrade but my friends T7600 2,33Ghz was always running very hot. The pins on the Core Duo and the Core 2 Duo are the same also for T7400 and T7600. Long back in 2007 I upgraded my Mac Mini Solo to a 2.0Ghz Core Duo (Not Core 2) because it was really cheap. Newegg does not carry them any more at least. It is not easy to get hold of the T7400 2.16Ghz like you have mayer but if you find one I think they are the best value speed/cpu temperature. ![]() ![]() ![]() ![]() Please contact our Support Service at to reclaim your update.ĭoes it work with the latest Apple Silicon M1/M2 based Macs? You are eligible for a special update for you current version of Microsoft NTFS for Mac by Paragon Software. I’m a user of a Seagate or Western Digital device with pre-installed NTFS for Mac. ![]() After that it will be locked until you activate a purchased license. Sure, you can try Microsoft NTFS for Mac by Paragon Software for ten days completely for free. Microsoft NTFS for Mac by Paragon Software is compatible with popular virtualization and encryption applications including VMware Fusion and Workstation, Parallels Desktop, TrueCrypt and its forks.Ĭould I try your product for free before buying? 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ARM-based Mac devices (Apple Silicon M1/-Pro/-Max/-Ultra/M2)Īll Microsoft NTFS versions are supported (from Windows NT 3.1 to Windows 10). ![]() ![]() ![]() In addition to the resting and desensitized structures ( Ruan et al., 2020), an open conformation of PAC was recently reported ( Wang et al., 2022). For example, the E94R mutant displays fast desensitization even at pH 5.0, when the wild-type channel does not exhibit obvious current decay ( Osei-Owusu et al., 2022b). This is regulated by several key residues localized at the ECD–TMD ( Osei-Owusu et al., 2022b). The desensitization of PAC is pH-dependentthat is, under more acidic conditions, desensitization is stronger ( Osei-Owusu et al., 2022b). After prolonged exposure to pH 4.6 or below, the PAC channel slowly desensitizes ( Osei-Owusu et al., 2022b). The proton binding to the ECD is directly coupled with the channel opening in the transmembrane domain (TMD) ( Osei-Owusu et al., 2022a). PAC channel is closed at neutral pH and becomes activated when the pH drops below 5.5 ( Yang et al., 2019). PAC is a homotrimer that forms a chloride-selective pore in the membrane, and it senses changes in pH via its large extracellular domain (ECD) ( Deng et al., 2021 Osei-Owusu et al., 2022a Ruan et al., 2020 Wang et al., 2022). This subsequently causes cellular swelling and contributes to acid-induced brain injury ( Osei-Owusu et al., 2020 Yang et al., 2019). For example, upon ischemic stroke, PAC is activated by drops in tissue pH, allowing the entry of chloride into the cells. In addition to localizing to the intracellular organelles, PAC also traffics to the plasma membrane, where it is involved in several pathological conditions associated with acidosis. During macropinocytosis PAC mediates the shrinkage of macropinosomes by releasing chloride into the cytoplasm ( Zeziulia et al., 2022). Thereby, PAC actively regulates luminal acidification by depleting the counter ion, chloride, and preventing proton accumulation in the endosome ( Osei-Owusu et al., 2021). In the endosome, low luminal pH activates PAC to mediate chloride efflux from the lumen. Since the recent discovery of its molecular identity ( Yang et al., 2019 Ullrich et al., 2019), PAC has been implicated in important biological functions, such as endosomal trafficking and macropinocytosis ( Osei-Owusu et al., 2021 Zeziulia et al., 2022). Proton-activated chloride channel PAC (also known as acid-sensitive outwardly rectifying anion channel or ASOR) is an evolutionarily conserved membrane protein with ubiquitous expression across different tissues. ![]() Our findings identify PIP 2 as a new pharmacological tool for the PAC channel and lay the foundation for future drug discovery targeting this channel. Structural and electrophysiological analyses suggest that PIP 2 inhibits the PAC channel by stabilizing the channel in a desensitized-like conformation. While the overall conformation resembles the previously resolved PAC structure in the desensitized state, the TMD undergoes remodeling upon PIP 2-binding. We solved the cryo-electron microscopy structure of PAC with PIP 2 at pH 4.0 and identified its putative binding site, which, surprisingly, locates on the extracellular side of the transmembrane domain (TMD). ![]() Here, we report that phosphatidylinositol (4,5)-bisphosphate (PIP 2) potently inhibits PAC channel activity. However, the pharmacology of the PAC channel is poorly understood. It is also found at the cell surface, where it is activated under pathological conditions related to acidosis and contributes to acid-induced cell death. PAC regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens. Proton-activated chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel, encoded by PACC1 ( TMEM206). ![]() ![]() ![]() The pools, too, are smaller, but there are more of them, spread out around the ship. This gives this area of the ship a more adult "date night" feel (although teens seemed to gravitate to the Kaito sushi, with its conveyor belt). The effect is that you feel more like you're in a land restaurant, than a large dining hall.Īnother thing that works on MSC Seashore, as opposed to other Seaside-class ships: the specialty restaurants are all grouped together in one space on Deck 8, instead of close to the buffet. MSC Seashore has four smaller main dining rooms as opposed to one large one, similar to what you'd find on Celebrity's Edge-class ships. One thing that works about MSC Seashore's deck plan is that the spaces onboard feel intimate - a feat on such a large ship. MSC Seashore's Deck Plan Has Multiple Pools, Multiple Restaurants to Break Up Crowds The ship's activities were accessible for Americans, while still appealing to MSC's international passenger base (even in the U.S., you'll find multiple languages spoken onboard).Īnd if you don't want to do anything and just relax, MSC Seashore has plenty of opportunities for that too, with a huge thermal suite and that European vibe that encourages you to relax - you're on vacation. The staff onboard couldn't be more cheerful, friendly or accommodating. On our sailing, there were no more lengthy waits in the dining rooms. On MSC Seashore, gone are some issues that plagued other MSC ships in their early days of U.S. And the Yacht Club on MSC Seashore is the line's largest so far, for those who want an upscale experience on a vessel with megaship amenities. The family-friendly quotient is high, with MSC's largest Doremi kids club, and a pirate-themed waterpark. The design of the ship is contemporary, with a splashy New York theme, a flashy (literally, lights go on all the time) Atrium and MSC's signature Swarovski crystal stairs. Huge in Europe and other parts of the world, MSC Cruises is still gaining ground in North America and in Miami, where MSC Seashore is based.Īnd that's too bad, because as the line's first Seaside EVO-class cruise ship, the 4,540-passenger MSC Seashore deserves attention. ![]() MSC Seashore and cruise line, MSC Cruises, might not be household names in all of the ports where the ship sails. ![]() ![]() Download CmapTools 604 for Windows for free without any viruses from Uptodown. 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Since 2018, Google has gradually sunsetted the Play brand: Play Newsstand was rebranded as Google News in 2018 Play Music was discontinued in favor of YouTube Music in 2020 and Play Movies & TV was rebranded as Google TV in 2021.Ĭatalog content Android applications įurther information: Android (operating system) Global availability of Google Playīy 2017, Google Play featured more than 3.5 million Android applications. Following their rebranding, Google has expanded the geographical support for each of the services. Google Play was launched on March 6, 2012, bringing together Android Market, Google Music, Google Movies, and the Google eBookstore under one brand, marking a shift in Google's digital distribution strategy. It has been the subject of multiple issues concerning security, in which malicious software has been approved and uploaded to the store and downloaded by users, with varying degrees of severity. The Google Play Store had over 82 billion app downloads in 2016 and over 3.5 million apps published in 2017, while after a purge of apps, it is back to over 3 million. Applications utilizing the hardware capabilities of a device can be targeted at users of devices with specific hardware components, such as a motion sensor (for motion-dependent games) or a front-facing camera (for online video calling). They can be downloaded directly on an Android device through the proprietary Google Play Store mobile app or by deploying the application to a device from the Google Play website. Content that has been purchased on Google Play Movies & TV and Google Play Books can be accessed on a web browser and through the Android and iOS apps.Īpplications are available through Google Play either for free or at a cost. Google Play has also served as a digital media store, offering games, music, books, movies, and television programs. It serves as the official app store for certified devices running on the Android operating system and its derivatives, as well as ChromeOS, allowing users to browse and download applications developed with the Android software development kit (SDK) and published through Google. Google Play, also known as the Google Play Store and formerly Android Market, is a digital distribution service operated and developed by Google. 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We collect and process personal data to provide you the Services, fulfill our contractual responsibility to deliver the Services to our Customers, fulfill your requests, and pursue our legitimate interests and our business and commercial purposes. In this Section we set out general categories of personal data we may collect and the purpose for using your personal data, including the personal data collected and processed over the past year. Personal Data We Collect About You and Why. Where we serve as a data processor, our Customer contracts and policies require us to either instruct you to contact our Customer, or redirect your inquiry to our Customer. For example, if you applied to a job at a local state agency, you should contact that agency with any questions you may have relating to the personal data processing by that state agency within our Services. This Policy does not describe the processing of your personal data by our Customers, and we encourage you to visit the Customer’s privacy policy for information about their privacy practices. Our legal obligations as a processor and service provider are set out in our Customer contracts and policies.įor instance, if you apply to a job or your employer utilizes our Services to manage their relationship with you, the personal data collected about you is generally controlled by the employer (our Customer). When we provide our Services to our Customers, the Customer generally controls and manages the personal data, and we process personal data as a data processor or service provider. Our Customers are organizations such as federal, state, local, tribal, or other municipal government agencies (including administrative agencies, departments, and offices thereof), private businesses, and educational institutions (including without limitation K-12 schools, colleges, universities, and vocational schools), who use our Services to evaluate job applicants and manage their relationship with their personnel. We are the controller for the personal data discussed in this Policy, except as noted in the “Where We Are a Service Provider” section below. We use Platform Data to provide Customers with useful and relevant insights, build features and data services, and improve our Services. This Policy does not apply to (1) personal data controlled by our Customers (employers that utilize our Services, described further below) (2) personal data collected by unaffiliated sites that link to or are accessible from our Services (3) personal data our partners may collect directly from you and control (4) personal data collected and processed by us about our employees or job applicants responding to our job offers and, (5) non-personal data derived from personal data, including any data that is aggregated, de-identified, or anonymized, statistical data, insights, or other predictive data that is sufficiently different from your personal data that it cannot be reversed engineered through reasonable means, or otherwise identified from analysis or further processing of the derived data (collectively referred to as the “Platform Data”). Any dispute related to privacy is subject to the Terms of Use and this Policy, including limitations on liability. ![]() ![]() Definitions not explicitly defined herein shall retain the meaning as prescribed in the Terms of Use. ![]() This Policy is incorporated into our Terms of Use. (DBA “NEOGOV”), including our related brands, ,, , and our mobile app(s) (collectively referred to as the “Services”), or affiliated companies (collectively referred to herein as “Governmentjobs”, "Schooljobs", “NEOGOV”, “NEOED”, “we”, “us”, or “our”).īy using any part of the Services you agree that you have read this policy, your personal data will be processed as described herein, and you agree to be bound by this Policy. This Policy applies to personal data we collect or use, and applications owned or controlled by, Inc. The purpose of this Privacy Policy (the “Policy”) is to describe how we collect, use, store, protect, and disclose personal data online and offline either via our websites or related applications. ![]() ![]() ![]() They do have the option to pre-pay for drinks at a discount, but there is no unlimited drink option on Virgin Voyages sailings.
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